EMT

[Molecular Cancer Research] Researchers found that the expression of DCLK1 isoform 4 (DCLK1-S) was significantly increased in human esophageal squamous cell carcinoma tissues and associated with malignant progression and poor prognosis.

[Scientific Reports] Researchers investigated the effects of p53 in primary sensitivity and acquired resistance to EGFR-TKIs in NSCLC cells.

[Cell Death Discovery] The Transwell assay and xenograft nude model showed that LHPP inhibited migration and invasion of colorectal cancer cells in vitro and in vivo, respectively. The expression of total and nuclear epithelial-to-mesenchymal transition-related proteins were significantly reduced after LHPP upregulation.

[iScience] Potential interactors of epithelial cell adhesion molecule (EpCAM) were identified in murine F9 teratoma cells using a SILAC-based proteomic approach. Endocytosis and membrane recycling were means of regulation of EpCAM protein levels during differentiation of ESCs and epithelial-to-mesenchymal transition induction in carcinoma cells.

[Oncogene] Scientists investigated the loss of SOX4 in mammary tumor development utilizing organoids derived from a PyMT genetic mouse model of breast cancer.

[Cancer Gene Therapy] Researchers found that the RNA-binding protein LIN28B, a known regulator of microRNA biogenesis, stem cell maintenance, and oncogenesis, was expressed in a subpopulation of cholangiocarcinoma patients.