EMT

[Cell Reports] Investigators mapped the cleavage site to Asn654-Leu655 and demonstrated that cleavage inhibition of wild-type anaplastic lymphoma kinase significantly impeded neuroblastoma cell migration with subsequent prolongation of survival in mouse models.

[Carcinogenesis] Researchers investigated the role and underlying mechanism of AGAP2-AS1 in prostate cancer (PCa). AGAP2-AS1 was confirmed to be highly expressed in PCa cells.

[RNA Biology] Researchers discovered that ZBED3 antisense RNA 1 (ZBED3-AS1) was overexpressed in melanoma cells compared with human epidermal melanocytes.

[Nature Communications] Scientists reported that cells derived from claudin-low mammary tumors, a mesenchymal subtype of triple-negative breast cancer, exhibited a distinctive organoid structure with extended “spikes” in 3D matrices.

[BMC Cancer] The potential functions of long intergenic non-protein coding RNA 1287 (LINC01287) were evaluated by cell viability assay, colony formation assay, soft agar assay, flow cytometry, transwell migration and invasion assay, and tumor xenograft growth in colon cancer cells.

[Thoracic Cancer] Researchers found that the SET domain containing 1A (SETD1A), the enzyme for methylation of histone 3 lysine 4, was elevated in lung cancer tissue compared to normal lung tissue.