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Mammary Cell News
DNAJB9 Suppresses the Metastasis of Triple-Negative Breast Cancer by Promoting FBXO45-Mediated Degradation of ZEB1
[Cell Death & Disease] The authors found that ectopic restoration of DNAJB9, a member of the heat shock protein 40 family, inhibited the migration, invasion, in vivo metastasis, and lung colonization of TNBC cells by inhibiting the epithelial–mesenchymal transition and metastasis.
Dermal Cell News
Loss of Ambra1 Promotes Melanoma Growth and Invasion
[Nature Communications] Scientists provided evidence that the Activating Molecule in Beclin-1-Regulated Autophagy (Ambra1) contributed to melanoma development.
Hepatic Cell News
Tspan5 Promotes Epithelial-Mesenchymal Transition and Tumour Metastasis of Hepatocellular Carcinoma by Activating Notch Signalling
[Molecular Oncology] Mechanistic studies revealed that Tspan5 promoted cell migration and tumour metastasis by increasing the enzymatic maturation of ADAM10 and activating Notch signalling via the increase of the cleavage of the Notch1 receptor catalysed by the γ‐secretase complex.
Hepatic Cell News
Histone Deacetylase Inhibitor Resminostat in Combination with Sorafenib Counteracts Platelet-Mediated Pro-tumoral Effects in Hepatocellular Carcinoma
[Scientific Reports] The impact of platelets on the sorafenib and resminostat drug effects in hepatocellular carcinoma cells was explored.
Pulmonary Cell News
Triptolide Suppresses the Growth and Metastasis of Non-small Cell Lung Cancer by Inhibiting β-Catenin-Mediated Epithelial–Mesenchymal Transition
[Acta Pharmacologica Sinica] Researchers investigated the effect of triptolide on the migration and invasion of non-small cell lung cancer cell lines.
Pulmonary Cell News
Schisandrin B Inhibits Epithelial-Mesenchymal Transition and Stemness of Large-Cell Lung Cancer Cells and Tumorigenesis in Xenografts via Inhibiting the NF-κB and p38 MAPK Signaling...
[Oncology Reports] established cancer stem‑like cells derived from large‑cell lung cancer cells, NCI‑H460 and H661, and revealed that Schisandrin B inhibited the viability of cancer stem‑like cells at concentrations of ≥40 µmol/l.