Researchers investigated the effect of triptolide on the migration and invasion of non-small cell lung cancer cell lines.
[Acta Pharmacologica Sinica]
7753456 {7753456:RG6542NG} apa 50 1 161708 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-0c2257f91606a6ae6dd8be887fdc20a8%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22RG6542NG%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Deng%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-23%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDeng%2C%20Q.%2C%20Lei%2C%20X.%2C%20Zhong%2C%20Y.%2C%20Chen%2C%20M.%2C%20Ke%2C%20Y.%2C%20Li%2C%20Z.%2C%20Chen%2C%20J.%2C%20Huang%2C%20L.%2C%20Zhang%2C%20Y.%2C%20Liang%2C%20L.%2C%20Lin%2C%20Z.%2C%20Liu%2C%20Q.%2C%20Li%2C%20S.%2C%20%26amp%3B%20Yu%2C%20X.%20%282021%29.%20Triptolide%20suppresses%20the%20growth%20and%20metastasis%20of%20non-small%20cell%20lung%20cancer%20by%20inhibiting%20%26%23x3B2%3B-catenin-mediated%20epithelial%26%23x2013%3Bmesenchymal%20transition.%20%3Ci%3EActa%20Pharmacologica%20Sinica%3C%5C%2Fi%3E%2C%201%26%23x2013%3B12.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41401-021-00657-w%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41401-021-00657-w%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DRG6542NG%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Triptolide%20suppresses%20the%20growth%20and%20metastasis%20of%20non-small%20cell%20lung%20cancer%20by%20inhibiting%20%5Cu03b2-catenin-mediated%20epithelial%5Cu2013mesenchymal%20transition%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiu-di%22%2C%22lastName%22%3A%22Deng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xue-ping%22%2C%22lastName%22%3A%22Lei%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yi-hang%22%2C%22lastName%22%3A%22Zhong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Min-shan%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuan-yu%22%2C%22lastName%22%3A%22Ke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhan%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jing%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Li-juan%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yu%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lu%22%2C%22lastName%22%3A%22Liang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhong-xiao%22%2C%22lastName%22%3A%22Lin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qing%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Song-pei%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xi-yong%22%2C%22lastName%22%3A%22Yu%22%7D%5D%2C%22abstractNote%22%3A%22Non-small%20cell%20lung%20cancer%20%28NSCLC%29%20is%20characterized%20by%20a%20high%20incidence%20of%20metastasis%20and%20poor%20survival.%20As%20epithelial%5Cu2013mesenchymal%20transition%20%28EMT%29%20is%20well%20recognized%20as%20a%20major%20factor%20initiating%20tumor%20metastasis%2C%20developing%20EMT%20inhibitor%20could%20be%20a%20feasible%20treatment%20for%20metastatic%20NSCLC.%20Recent%20studies%20show%20that%20triptolide%20isolated%20from%20Tripterygium%20wilfordii%20Hook%20F%20attenuated%20the%20migration%20and%20invasion%20of%20breast%20cancer%2C%20colon%20carcinoma%2C%20and%20ovarian%20cancer%20cells%2C%20and%20EMT%20played%20important%20roles%20in%20this%20process.%20In%20the%20present%20study%20we%20investigated%20the%20effect%20of%20triptolide%20on%20the%20migration%20and%20invasion%20of%20NSCLC%20cell%20lines.%20We%20showed%20that%20triptolide%20%280.5%2C%201.0%2C%202.0%5Cu2009nM%29%20concentration-dependently%20inhibited%20the%20migration%20and%20invasion%20of%20NCI-H1299%20cells.%20Triptolide%20treatment%20concentration-dependently%20suppressed%20EMT%20in%20NCI-H1299%20cells%2C%20evidenced%20by%20significantly%20elevated%20E-cadherin%20expression%20and%20reduced%20expression%20of%20ZEB1%2C%20vimentin%2C%20and%20slug.%20Furthermore%2C%20triptolide%20treatment%20suppressed%20%5Cu03b2-catenin%20expression%20in%20NCI-H1299%20and%20NCI-H460%20cells%2C%20overexpression%20of%20%5Cu03b2-catenin%20antagonized%20triptolide-caused%20inhibition%20on%20EMT%2C%20whereas%20knockout%20of%20%5Cu03b2-catenin%20enhanced%20the%20inhibitory%20effect%20of%20triptolide%20on%20EMT.%20Administration%20of%20triptolide%20%280.75%2C%201.5%5Cu2009mg%5C%2Fkg%20per%20day%2C%20ip%2C%20every%202%20days%29%20for%2018%20days%20in%20NCI-H1299%20xenograft%20mice%20dose-dependently%20suppressed%20the%20tumor%20growth%2C%20restrained%20EMT%2C%20and%20decreased%20lung%20metastasis%2C%20as%20evidence%20by%20significantly%20decreased%20expression%20of%20mesenchymal%20markers%2C%20increased%20expression%20of%20epithelial%20markers%20as%20well%20as%20reduced%20number%20of%20pulmonary%20lung%20metastatic%20foci.%20These%20results%20demonstrate%20that%20triptolide%20suppresses%20NSCLC%20metastasis%20by%20targeting%20EMT%20via%20reducing%20%5Cu03b2-catenin%20expression.%20Our%20study%20implies%20that%20triptolide%20may%20be%20developed%20as%20a%20potential%20agent%20for%20the%20therapy%20of%20NSCLC%20metastasis.%22%2C%22date%22%3A%222021-04-23%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41401-021-00657-w%22%2C%22ISSN%22%3A%221745-7254%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41401-021-00657-w%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%2243ZBJFKZ%22%5D%2C%22dateModified%22%3A%222021-04-26T21%3A31%3A37Z%22%7D%7D%5D%7D
Deng, Q., Lei, X., Zhong, Y., Chen, M., Ke, Y., Li, Z., Chen, J., Huang, L., Zhang, Y., Liang, L., Lin, Z., Liu, Q., Li, S., & Yu, X. (2021). Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-catenin-mediated epithelial–mesenchymal transition. Acta Pharmacologica Sinica, 1–12. https://doi.org/10.1038/s41401-021-00657-w Cite