EMT

[Acta Pharmacologica Sinica] Scientists found that cinobufotalin (CB) decreased cisplatin (DDP) resistance, migration and invasion in lung adenocarcinoma and showed that CB induced ENKUR expression by suppressing PI3K/AKT signaling to downregulate c-Jun, a negative transcription factor of ENKUR.

[Experimental Cell Research] Scientists studied the effects of miR-127-3p-enriched extracellular vesicles on choriocarcinoma and underlying mechanisms.

[Cell Reports] Investigators showed that collapsin response mediator protein 2A (CRMP2A) was unexpectedly and reversibly induced in cancer cells in response to multiple metabolic stresses, including low glucose and hypoxia, and inhibited EMT/stemness.

[Glycoconjugate Journal] The authors indicate that GD3 synthase contributes to gefitinib resistance in epidermal growth factor receptor-positive breast cancer cells, and is a potentially useful therapeutic target in drug-resistant breast cancers.

[BMC Cardiovascular Disorders] Investigators probed the therapeutic effects of MSC-derived exosomes on myocardial fibrosis after myocardial infarction and possible mechanisms.

[Breast Cancer Research and Treatment] MDA-MB-231-HM cells secreted exosomes enriched matrix metalloproteinase-1 (MMP-1), which could be taken up and enhanced invasion and migration activities of TNBC cells, including MDA-MB-231, MDA-MB-468 and BT549.