The Small Molecule Chemical Compound Cinobufotalin Attenuates Resistance to DDP by Inducing ENKUR Expression to Suppress MYH9-Mediated C-Myc Deubiquitination in Lung Adenocarcinoma

Scientists found that cinobufotalin (CB) decreased cisplatin (DDP) resistance, migration and invasion in lung adenocarcinoma and showed that CB induced ENKUR expression by suppressing PI3K/AKT signaling to downregulate c-Jun, a negative transcription factor of ENKUR.