EMT

[Translational Oncology] Silencing of TIM-3 shuttled by MV3 cells-derived exosomes improved CD4+ T cell immune function and inhibited macrophage M2 polarization to attenuate the growth and metastasis of melanoma cells.

[Cell Death Discovery] Utilizing an integrated strategy based on scRNA-seq, scTCR-seq, and bulk RNA-seq analysis of fibrotic hypersensitivity pneumonitis profiles, the authors identified ten major cell types and 19 unique subtypes.

[Cell Death & Differentiation] Researchers revealed a novel oncogenic function of IKBKE in promoting breast cancer metastasis by governing Snail abundance, and highlighted the potential of targeting IKBKE for metastatic breast cancer therapies.

[Oncogene] The authors report the prognostic value, clinical relevance, and biological significance of the Nischarin gene in breast cancer patients using the Molecular Taxonomy of Breast Cancer International Consortium and The Cancer Genome Atlas datasets.

[Cell Death & Disease] NR2F1-AS1 and NR2F1 were highly co-expressed in pan-tissues and pan-cancers. Depletion of NR2F1-AS1 compromised the expression level of NR2F1 in gastric cancer cells.

[Cellular and Molecular Life Sciences] The authors review the clinical significance of mesenchymal circulating tumor cells (CTCs) in breast cancer together with statistical analysis of previously published data, in which they assess the suitability of a number of methods/markers used for isolation of CTCs with different epithelial-mesenchymal transition phenotypes.