GWAS

[Nature Communications] Scientists integrated human genetics with transcriptomic data from differentiation of human ESCs into cortical excitatory neurons.

[American Journal of Human Genetics] The authors assessed the utility of chromosome conformation capture coupled with immunoprecipitation (HiChIP) to identify target genes for prostate cancer genome-wide association studies risk loci.

[Molecular Psychiatry] Scientists utilized patient-derived iPSCs to generate 3D cerebral organoids to model neuropathology of schizophrenia during its early-arising neurodevelopmental period.

[Translational Psychiatry] Utilizing iPSCs from 25 human donors, researchers generated 3D cerebral organoids, employed 16-plex isobaric sample-barcoding chemistry, and simultaneously subjected samples to comprehensive high-throughput liquid-chromatography/mass-spectrometry quantitative proteomics.

[BMC Genomics] The objective of this study was to identify genomic regions with a biological relevance for the immunocompetence of piglets. Genome-wide Association Studies in 535 Landrace and 461 Large White piglets were performed, investigating 20 immune relevant traits.

[American Journal of Human Genetics] Scientists proposed that intracellular accumulation of a nonfunctional chymotrypsinogen B2 protein led to endoplasmic reticulum stress and pancreatic inflammation, which might explain the increased pancreatic cancer risk in carriers of CTRB2 exon 6 deletion alleles.