HIF

[Science Signaling] Scientists demonstrated that cyclin J, a TLR-inducible member of the cyclin family, reduced cytokine production in macrophages by coordinately controlling glycolysis and mitochondrial functions.

[Nature Cardiovascular Research] Investigators characterized vascular aberrancies induced by myocardial infarction (MI) and proposed to target acquired endothelial cell changes to normalize vessels and promote cardiac repair after MI.

[BMC Pulmonary Medicine] In vitro, Jagged1 was found to be activated by Notch1 in MSCs, resulting in the RBP-Jκ-dependent expression of Jagged1 mRNA, a response that was blocked by Notch1 inhibition.

[Science Translational Medicine] In response to PX-478 treatment, human islet organoids chronically exposed to high glucose presented improved stimulation index of glucose-induced insulin secretion.

[Cell Death & Differentiation] The authors illustrated that HIF-2α, but not HIF-1α, induced stemness in breast cancer cells under hypoxia through SOD2-mtROS-PDI/GRP78-UPRER pathway, linking mitochondrial metabolic state to endoplasmic reticulum response via mitochondrial reactive oxygen species level.

[Annals of Medicine] The authors comprehensively review the role of high-mobility group box 1 (HMGB1), hypoxia-inducible factor-1α (HIF-1α), and VEGF in doxorubicin-induced cardiovascular disease and its molecular mechanisms.