HUVECs

[Chemico-Biological interactions] Scientists synthesized a series of small molecule compounds with the potential to inhibit eIF4E. Among them, the compound EGPI-1 significantly inhibited the proliferation of a variety of lung cancer cells such as A549, NCI-H460, NCI-H1650 and 95D without inhibiting the proliferation of HUVEC cells.

[Microvascular Research] Investigators found that sodium dithionite induced endothelial cell tube formation without matrigel under hypoxia conditions. The angiogenesis related proteins and mRNA at different time points after tube formation were measured both in primary HUVECs and murine microvascular endothelial cell lines.

[Applied Materials Today] Scientists showed that MSCs cultured in hPL displayed a reduced cell size and cell spreading, but an improved proliferation and osteogenic capability compared with cells maintained in fetal bovine serum.

[Hypertension Research] Hypoxia increased α1-AR and vascular endothelial growth factor (VEGF) mRNA levels in adipose-derived stem cells. Norepinephrine further increased VEGF mRNA expression under hypoxia; this effect was abolished by doxazosin.

[Aging] The authors investigated the effects of bone morphogenetic protein 9 on osteogenesis and angiogenesis of human amniotic mesenchymal stem cells (hAMSCs) cocultured with human umbilical vein endothelial cells (HUVECs) and determined the possible underlying molecular mechanism.

[Stem Cell Research & Therapy] The authors investigated whether sevoflurane preconditioning could promote MSCs to attenuate myocardial I/R injury via transient receptor potential canonical channel 6 (TRPC6)-induced angiogenesis.