EGPI-1, a Novel eIF4E/eIF4G Interaction Inhibitor, Inhibits Lung Cancer Cell Growth and Angiogenesis through Ras/MNK/ERK/eIF4E Signaling Pathway

Scientists synthesized a series of small molecule compounds with the potential to inhibit eIF4E. Among them, the compound EGPI-1 significantly inhibited the proliferation of a variety of lung cancer cells such as A549, NCI-H460, NCI-H1650 and 95D without inhibiting the proliferation of HUVEC cells.