IL-1B

[Frontiers in Oncology] Investigators found that AML cells released a heterogeneous population of extracellular vesicles containing microRNAs involved in AML pathogenesis.

[Molecular Therapy-Nucleic Acids] Scientists developed a transgenic mouse line overexpressing the circular RNA circNlgn and showed that circNlgn was a mediator of Doxorubicin-induced cardio-fibrosis.

[EMBO Journal] Investigators showed that the nucleocapsid of SARS-CoV-2 inhibited host pyroptosis by blocking Gasdermin D cleavage. SARS-CoV-2-infected monocytes showed enhanced cellular interleukin 1b (IL-1b) expression, but reduced IL-1b secretion.

[npj Breast Cancer] Scientists investigated how IL-1B from tumour cells and the microenvironment interacted to affect primary tumour growth and bone metastasis through regulation of the immune system, and whether targeting IL-1 driven changes to the immune response improved standard of care therapy for breast cancer bone metastasis.

[Experimental Eye Research] Scientists evaluated the effect of the conditioned medium secreted by human Wharton's jelly MSCs (WJMSCs-CM) on the proliferation and apoptosis gene expression of the retinal pigmented epithelium.

[Molecular Therapy-Methods & Clinical Development] Scientists investigated their interplay in vascular smooth muscle cell inflammation. Chromatin immunoprecipitation followed by high-throughput sequencing revealed H3K27ac/BRD4 enrichment at CCAAT enhancer binding protein delta (Cebpd) in injured rat carotid arteries.