IL-1B Drives Opposing Responses in Primary Tumors and Bone Metastasis; Harnessing Combination Therapies to Improve Outcome in Breast Cancer

Scientists investigated how IL-1B from tumour cells and the microenvironment interacted to affect primary tumour growth and bone metastasis through regulation of the immune system, and whether targeting IL-1 driven changes to the immune response improved standard of care therapy for breast cancer bone metastasis.