IL-6

[Frontiers in Endocrinology] Cord blood samples were obtained from 104 term infants, including 47 exposed to maternal diabetes. Leptin, insulin, and IL-6 were quantified by multiplex assay.

[Communications Biology] The authors showed that clinically, plasma interleukin-6 (IL-6) level predicted osimertinib efficacy in epidermal growth factor receptor mutant NSCLC patients.

[Scientific Reports] Murine splenocytes were differentiated into T helper 17 cells, and the effect of the TGF-βRI inhibitor SB-505124 was studied.

[Scientific Reports] Researchers examined whether haem oxygenase-1 (HO-1) could enhance the immunosuppressive effects of bone marrow MSCs (BMMSCs) on the rejection of transplanted liver allografts in rats.

[Frontiers in Immunology] Using a human in vitro tri-culture system of macrophages with activated autologous T cells and BRAFV600E mutant melanoma cells, scientists showed that activated T cells and the synthetic triterpenoid the methyl CDDO-Me attenuated immune suppression.

[EMBO Journal] Via targeted deletion of virus-recognition innate immune pathways, scientists identified TLR7-MyD88 signaling as crucial for production of antiviral interferons, whereas TLR2 is responsible for the inflammatory IL-6 response.