IL-6

[PLoS One] Brain-derived neurotrophic factor promoted hematopoietic regeneration via activation of PDGFRα+ bone marrow MSCs which increased secretion of hematopoietic cytokines interleukin 6 and leukemia inhibitory factor in response to TrkB activation.

[Cellular Reprogramming] MSCs were extracted from adipose, umbilical cord, and placental tissues. The expression levels of 80 cytokines were detected, and the data demonstrated that the three MSC types abundantly secreted insulin-like growth factor-binding protein (IGFBP)-4, IGFBP-3, tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, IGFBP-6, monocyte chemoattractant protein-1, and granulocyte colony-stimulating factor.

[Journal of Applied Microbiology] To evaluate anti-inflammatory activities of L. reuteri LM1071, LPS-stimulated RAW264.7 cells were used. Gene expression levels of eight immune-associated genes including IL-1β, IL-6, and TNF-α and protein production levels of COX-1 and COX-2 were analyzed.

[Journal of Virology] Scientists infected hiPSC-derived cardiomyocytes, from healthy human subjects, with SARS-CoV-2 in the absence and presence of IL-6 and IL-1β. Infection resulted in increased numbers of multinucleated cells.

[American Journal of Transplantation] Researchers performed full transcriptomic RNA sequencing and qPCR to evaluate the effects of mevalonate on the immunoregulatory phenotype of endothelial cells.

[Cell Death & Disease] Centrosomal P4.1-associated protein (CPAP) could increase the expression of chemokine ligand 16 (CCL-16), an important chemotactic cytokine in human hepatocytes. CCL-16 expression was positively correlated with CPAP and TNF-α mRNA expression in the peritumoral part of hepatocellular carcinoma.