IL-8

[International Archives of Allergy and Immunology] Cough-variant asthma (CVA) is a special type of asthma, solely manifesting with coughing. Investigators suggested that airway inflammation was associated with CVA pathogenesis.

[Stem Cells Translational Medicine] Allogeneic, bone marrow-derived MSCs were systemically administered into patients with stable chronic obstructive pulmonary disease. Gene expression profiles from peripheral blood mononuclear cells were analyzed across the first week after infusion.

[npj Regenerative Medicine] Scientists demonstrated that IL-8 was upregulated by the FGF2-mediated priming effect during FECS-Ad formation. Immobilized FGF2 substrate induced stronger IL-8 expression than soluble FGF2 ligands, presumably through the FGFR1/JNK/NF-κB signaling cascade.

[Pediatric Research] Scientists demonstrated that melatonin had several significant effects by reducing CD11b and TLR4 expression, attenuating TLR signaling, genes involved in the inflammasome and had the potential to reduce LPS-induced inflammatory responses.

[Scientific Reports] The authors found that the stimulation of human trabecular meshwork (TM) cells with monocyte chemoattractant protein (MCP)-1 and IL-8 induced significant increase in the formation of actin stress fibers and focal adhesions, myosin light chain phosphorylation, and the contraction of TM cells.

[Nature Cancer] Scientists established a novel mechanism by which castration mediated IL-8 secretion and subsequent polymorphonuclear myeloid-derived suppressor cells infiltration.