MAPK

[Molecular Medicine Reports] Human vascular smooth muscle cells were loaded with cholesterol and different concentrations of metformin. The expression levels of adhesion molecules were assessed via reverse transcription‑quantitative PCR and western blotting.

[Nature Aging] Researchers reported that mouse skin hair follicle stem cell (HFSC) aging was initiated by their intrinsic upregulation of miR-31, a microRNA that could be induced by physical injury or genotoxic stress and was also strongly upregulated in aged human skin epithelium.

[Molecular Cancer therapeutics] Researchers performed whole exome sequencing on BRAF-V600E mutant melanoma patient tumors refractory to the combination of BRAF/MEK inhibition and identified acquired oncogenic mutations in NRAS and loss of the tumor suppressor gene CDKN2A.

[Stem Cell Reports] Utilizing an induced pluripotent stem cell-derived endothelial cell (iPSC-EC) model, researchers showed that anti-complement factor H autoantibody-associated atypical hemolytic uremic syndrome patient-specific iPSC-ECs exhibited an intrinsic defect in endothelial functions.

[Medical Oncology] Researchers verified the resistance levels of parental and resistant PC3 prostate cancer cells to bortezomib using WST-1 test.

[International Immunopharmacology] The authors explored the protective effect and preliminary mechanism of Dioscin on dextran sulfate sodium (DSS)-induced colitis in mice and showed that Dioscin reduced DSS-induced disease activity index increase, colon length shortening and colon pathological damage.