Patient-Specific iPSC-Derived Endothelial Cells Reveal Aberrant p38 MAPK Signaling in Atypical Hemolytic Uremic Syndrome

Utilizing an induced pluripotent stem cell-derived endothelial cell (iPSC-EC) model, researchers showed that anti-complement factor H autoantibody-associated atypical hemolytic uremic syndrome patient-specific iPSC-ECs exhibited an intrinsic defect in endothelial functions.