MAPK

[Advanced Science] A low-cost protocol for cardiomyocyte differentiation from mouse ESCs is presented and it is shown that Pten deletion potently suppressed cardiomyocyte differentiation.

[Journal of Virology] Scientists showed that cell-free HIV-1 and its proteins gp120 and tat induce the disruption of tonsil epithelial tight junctions and increase paracellular permeability, which facilitates HCMV spread within the tonsil mucosa.

[Signal Transduction and Targeted Therapy] Scientists discuss the initiation and resolution of inflammation, the crosstalk between tumor development and inflammatory processes.

[Cancer Biology & Therapy] Scientists showed that fibroblast growth factor receptor 2 (FGFR2), particularly the IIIb isoform, was highly expressed in non-CSCs.

[Molecular Cell] Researchers interrogated the function of RNA-binding proteins (RBP) in cancer using pooled CRISPR-Cas9 screening and identified 57 RBP candidates with distinct roles in supporting MYC-driven oncogenic pathways in TNBC cells.

[Scientific Reports] Through a kinome-centered CRISPR-Cas9 screen in CWR-R1 prostate cancer cells, scientists identified activated BRAF signaling as a determinant for enzalutamide resistance.