MAPK

[Molecular Therapy-Nucleic Acids] Scientists screened multi-layer molecular data of 36 pancreatic cancer cell lines, including gene mutation, gene expression, miRNA expression, and protein profiles.

[Molecular Therapy-Nucleic Acids] Researchers reported a global m6A modification pattern of goat skeletal muscle at two key development stages and identified that the m6A modification regulated the expression of the growth arrest and DNA damage response 45B (GADD45B) gene, which was involved in myogenic differentiation.

[Cell Death & Disease] Scientists revealed that (+)-ND could repress osteoclast synthesis, bone resorption function in vitro, and attenuated ovariectomy-triggered bone loss in vivo.

[Life Sciences] The authors summarize the current knowledge on the cardiac signaling pathways modulated by two antineoplastic drugs highly used in the management of breast cancer, not only focusing on cardiomyocytes but also to broaden the knowledge of the potential impact on other cells found in the heart.

[Scientific Reports] Researchers identified genomic regions associated with resistance to Caligus rogercresseyi in Atlantic salmon and rainbow trout by performing single-step Genome-Wide Association studies, and identify candidate genes related to trait variation based on exploring orthologous genes within the associated regions across species.

[Cancer Research] Reserachers showed inhibition of glucose metabolism with low dose 2-deoxyglucose in combination with a MEK inhibitor induced apoptosis in KrasG12D-driven pancreatic ductal adenocarcinoma cells in vitro.