Tag results:
MAPK
Pulmonary Cell News
The Glucocorticoid Receptor Associates with RAS Complexes to Inhibit Cell Proliferation and Tumor Growth
[Science Signaling] The authors found that glucocorticoid receptor was present in cytoplasmic KRAS-containing complexes and inhibited the activation of wild-type and oncogenic KRAS in mouse embryonic fibroblasts and human lung cancer A549 cells.
Hematopoiesis News
Hematopoietic Stem Cells Temporally Transition to Thrombopoietin Dependence in the Fetal Liver
[Science Advances] Investigators found that HSCs temporally transitioned to depend on thrombopoietin, a key extrinsic factor, from E16.5 onward in the developing liver.
Dermal Cell News
Biosafety and Differentially Expressed Genes Analysis of Melanoma Cells Treated with Cold Atmospheric Plasma
[Journal of Biophotonics] Researchers evaluated cell viability, apoptosis rate, and reactive species injection efficiency of melanoma cells and human keratinocyte cells treated with cold atmospheric plasma and analyzed its biological safety.
Intestinal Cell News
Hsa-miR-186-3p Suppresses Colon Cancer Progression by Inhibiting KRT18/MAPK Signaling Pathway
[Cell Cycle] A biotin-microRNA pull-down assay was performed to identify potential miRNAs. qRT-PCR was used to verify the KRT18 and miR-186-3p levels.
Mammary Cell News
Tocilizumab Overcomes Chemotherapy Resistance in Mesenchymal Stem-Like Breast Cancer by Negating Autocrine IL-1A Induction of IL-6
[npj Breast Cancer] In order to gain insight into pathways that contributed to the divergent sensitivity to chemotherapy, scientists compared the inflammatory profile of the TNBC subtypes treated with docetaxel.
ESC & iPSC News
Incorporation of a Histone Mutant with H3K56 Site Substitution Perturbs the Replication Machinery in Mouse Embryonic Stem Cells
[Journal of Molecular Cell Biology] Scientists mimicked histone H3 at the 56th lysine (H3K56) mutant incorporation in mESCs by lentivirus-mediated ectopic expression and analyzed the effects on replication and epigenetic regulation.