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MAPK

The Glucocorticoid Receptor Associates with RAS Complexes to Inhibit Cell Proliferation and Tumor Growth

[Science Signaling] The authors found that glucocorticoid receptor was present in cytoplasmic KRAS-containing complexes and inhibited the activation of wild-type and oncogenic KRAS in mouse embryonic fibroblasts and human lung cancer A549 cells.

Hematopoietic Stem Cells Temporally Transition to Thrombopoietin Dependence in the Fetal Liver

[Science Advances] Investigators found that HSCs temporally transitioned to depend on thrombopoietin, a key extrinsic factor, from E16.5 onward in the developing liver.

Biosafety and Differentially Expressed Genes Analysis of Melanoma Cells Treated with Cold Atmospheric Plasma

[Journal of Biophotonics] Researchers evaluated cell viability, apoptosis rate, and reactive species injection efficiency of melanoma cells and human keratinocyte cells treated with cold atmospheric plasma and analyzed its biological safety.

Hsa-miR-186-3p Suppresses Colon Cancer Progression by Inhibiting KRT18/MAPK Signaling Pathway

[Cell Cycle] A biotin-microRNA pull-down assay was performed to identify potential miRNAs. qRT-PCR was used to verify the KRT18 and miR-186-3p levels.

Tocilizumab Overcomes Chemotherapy Resistance in Mesenchymal Stem-Like Breast Cancer by Negating Autocrine IL-1A Induction of IL-6

[npj Breast Cancer] In order to gain insight into pathways that contributed to the divergent sensitivity to chemotherapy, scientists compared the inflammatory profile of the TNBC subtypes treated with docetaxel.

Incorporation of a Histone Mutant with H3K56 Site Substitution Perturbs the Replication Machinery in Mouse Embryonic Stem Cells

[Journal of Molecular Cell Biology] Scientists mimicked histone H3 at the 56th lysine (H3K56) mutant incorporation in mESCs by lentivirus-mediated ectopic expression and analyzed the effects on replication and epigenetic regulation.

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