MTOR

[Nature Communications] The authors demonstrated that lymphoid-restricted mutant IL7R, expressed at physiological levels in conditional knock-in mice, established a pre-leukemic stage in which B cell precursors displayed self-renewal ability, initiating leukemia resembling PAX5 P80R or Ph-like human B-acute lymphoblastic leukemia.

[British Journal of Nutrition] Researchers investigated the role and underlying molecular mechanism of Tau on protein synthesis and proliferation of C2C12 myoblast cells.

[Scientific Reports] Scientists performed fully-mismatched heart transplantations and found combination treatment to result in prolonged allograft survival.

[Evidence-Based Complementary and Alternative Medicine] The expression level of relative proteins in mTOR pathway was detected by western blot assay to investigate the mechanism of Qingjie Fuzheng granule effect on colorectal cancer cells.

[Scientific Reports] The authors investigated miR1908-5p function by leveraging human primary hepatocytes and HuH-7 hepatoma models and implicated miR1908-5p in metabolic and energy regulation in hepatocyte models via multiple, independent, pathways.

[PLoS One] Activated hepatic stellate cell cell lines were used to evaluate the effects of tenofovir disoproxil fumarate and entecavir. After treatment with each antiviral agent, cell viability, morphology, apoptotic features, autophagy and antifibrosis signaling pathways were examined.