Tenofovir Disoproxil Fumarate Directly Ameliorates Liver Fibrosis by Inducing Hepatic Stellate Cell Apoptosis via Downregulation of PI3K/Akt/mTOR Signaling Pathway

Activated hepatic stellate cell cell lines were used to evaluate the effects of tenofovir disoproxil fumarate and entecavir. After treatment with each antiviral agent, cell viability, morphology, apoptotic features, autophagy and antifibrosis signaling pathways were examined.