MTOR

[Cell Metabolism] The authors reported that a fasting-mimicking diet activated starvation escape pathways in TNBC cells, which could be identified and targeted by drugs. They found that metastatic TNBC patients with lower glycemia survived longer than those with higher baseline glycemia.

[Molecular Cancer Research] Scientists address the mechanistic progress on how PRK-like endoplasmic reticulum kinase (PERK) acts as a multifunctional molecule to commit 17β-estradiol to inducing apoptosis in endocrine-resistant breast cancer.

[Stem Cells International] Scientists investigated the efficacy of miR-20a overexpressing adipose-derived stem cell transplantation in murine lupus nephritis and explored potential molecular mechanisms.

[Scientific Reports] Investigators used peripheral blood and bone marrow samples from patients with acute myeloid leukemia (AML) to analyze the impact of CD157-directed antibodies in AML survival and in response to cytarabine ex vivo.

[Cell Communication and Signaling] A dystrophin-deficient myoblast cell line established from the skeletal muscle of a dystrophic mouse was used as a model. The dfd13 and C2C12 myoblasts were cultured in low mitogen conditions for ten days to induce differentiation.

[Neoplasia] Scientists discovered that brain-type creatine kinase (CKB) was a negative regulator of epithelial-mesenchymal transition and AKT activation, which revealed a new mode of their regulation.