MTOR

[Ecotoxicology and Environmental Safety] Colony formation assay showed that the cells with AR, mTOR and DDIT3 knockdown could remarkably mitigate the cell proliferation ability in both PC-3 and LNCap cells.

[Cell Death Discovery] Investigators explored the repair effect of human umbilical cord MSCs-derived extracellular vesicles on spinal cord injury.

[Oncogene] Researchers found that NDRG1 enhanced the sensitivity of cetuximab in colorectal cancer cell lines by inhibiting the expression of epidermal growth factor receptor (EGFR); blocking EGFR phosphorylation and reducing the EGFR distribution in the cell membrane, cytoplasm and nucleus.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers investigated the mechanism of how SLC15A4 directed inflammatory responses. Proximity-dependent biotin identification revealed glycolysis as highly enriched gene ontology terms.

[Pharmacological Research] The authors review the mechanisms and treatment strategies for skeletal muscle atrophy.

[Nature Communications] Scientists generated conditional, inducible knock-out mice for Rpap3 to inactivate the HSP90 component of R2TP in the intestinal epithelium. Proliferative stem cells and progenitors deficient for Rpap3 failed to import RNA polymerase II into the nucleus and they induced p53, cell cycle arrest and apoptosis.