MYC

[Nature Immunology] Researchers identified that targeting the epigenetic modifier BMI-1 in mice improved humoral responses to chronic lymphocytic choriomeningitis virus.

[Cell Reports] Pharmacologic inhibition of CHK1 alone caused apoptotic growth suppression of both PDAC cell lines and organoids, which correlated with loss of MYC expression.

[Molecular Carcinogenesis] Scientists found that NUAK family kinase 2 (NUAK2) expression was elevated in prostate cancer and metastatic castration resistant PC versus normal tissue, and expression correlated with an increased risk of metastasis.

[Oncogene] Deregulation of CSN5, a putative androgen receptor (AR), could affect diverse cellular functions that contribute to tumor development. Inhibition of CSN5 repressed metabolic pathways, including oxidative phosphorylation and glycolysis in AR-negative prostate cancer cells.

[Cellular Oncology] The effect of BET inhibition was evaluated using iBET-151, a small-molecule inhibitor of BET proteins, in a large panel of gastric cancer cell lines and xenograft mouse models. The synergistic effect of iBET-151 and paclitaxel was evaluated using an organoid model.

[Molecular Cancer Research] Researchers revealed the breadth of SWI/SNF dependency in leukemia and supported targeting SWI/SNF catalytic function as a potential therapeutic strategy in acute myeloid leukemia.