Oct4

[Development] Investigators reported that the conjunct activity of two orphan nuclear receptors, Esrrb and Nr5a2, paralleled the importance of that of Oct4 and Sox2 in naïve ESCs.

[Journal of Cellular and Molecular Medicine] Researchers compared the therapeutic potential of induced pluripotent stem cells differentiation into MSCs generated from urinary epithelial cells with the available umbilical cord MSCs.

[Nature Cell Biology] Scientists systematically dissected OCT4 to show that nucleosome binding was encoded within the DNA-binding domain and yet could be uncoupled from free-DNA binding. They found that stable interactions between OCT4 and nucleosomes were continuously required for maintaining the accessibility of pluripotency enhancers in stem cells.

[International Journal of Biochemistry & Cell Biology] An ovarian cancer cell line, PEO4, was reprogrammed into iPSCs using the classical four factors OCT4, SOX2, KLF4 and MYC (OSKM) using lentivirus transduction.

[International Journal of Biochemistry & Cell Biology] An ovarian cancer cell line, PEO4, was initially reprogrammed into induced pluripotent stem cells using the classical four factors OCT4, SOX2, KLF4 and MYC using lentivirus transduction.

[Stem Cell Research] Natural killer cells were isolated from human umbilical cord blood from a healthy newborn and reprogrammed by episomal vectors carrying reprograming factors L-MYC, LIN28, OCT4, SOX2, KLF4, EBNA-1, and shRNA against p53 delivered using nucleofection.