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PBMCs

Adenosine Deaminase Modulates Metabolic Remodeling and Orchestrates Joint Destruction in Rheumatoid Arthritis

[Scientific Reports] Scientists presented an integrative analysis of clinical data, cytokines, serum metabolomics in rheumatoid arthritis patients and mechanistic studies on adenosine deaminase-mediated effects on in vitro cell culture models.

Immunologic Mechanisms of Seasonal Influenza Vaccination Administered by Microneedle Patch from a Randomized Phase I Trial

[NPJ Vaccines] Investigators compared the humoral and cellular immunologic responses in a subset of participants receiving influenza vaccination by microneedle patches to the intramuscular route of administration.

HLA-DR Cancer Cells Expression Correlates with T Cell Infiltration and Is Enriched in Lung Adenocarcinoma with Indolent Behavior

[Scientific Reports] Scientists identified cellular subpopulations of epithelial cancer cells and their microenvironment and validated their results by multiplex immunofluorescence applied to a tissue microarray of long and short-predicted survival lung adenocarcinoma.

The Immunoregulatory Function of Peripheral Blood CD71+ Erythroid Cells in Systemic-Onset Juvenile Idiopathic Arthritis

[Scientific Reports] The authors studied the gene expression and function in systemic-onset juvenile idiopathic arthritis to assess the biological role of CD71+ erythroid cells in systemic inflammation.

Itacitinib Prevents Xenogeneic GVHD in Humanized Mice

[Bone Marrow Transplantation] Mice were followed for xenogeneic graft-versus-host disease score and survival. Human T-cell engraftment and as well as human T-cell subtypes were monitored in blood on days 14, 21, and 28 after transplantation.

Understanding LRRK2 Kinase Activity in Preclinical Models and Human Subjects through Quantitative Analysis of LRRK2 and pT73 Rab10

[Scientific Reports] Researchers developed and applied such assays to measure the levels of leucine-rich repeat kinase 2 as well as the phosphorylation of LRRK2 itself or one of its substrates, Rab10.

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