PBMCs

[Stem Cell Reviews and Reports] Scientists provide an overview of promising easily accessible somatic cell sources isolated in non-invasive or minimally invasive manner such as keratinocytes, urine cells, and peripheral blood mononuclear cells used for the generation of human iPSCs derived from healthy and diseased subjects.

[iScience] RNA-sequencing analysis of zymosan-treated MSCs showed that calcineurin-NFAT inhibition affects extracellular matrix genes, but not cytokine expression that is under the control of the NF-κB pathway.

[Genes] To study the molecular mechanisms of Usher syndrome and develop a gene therapy strategy, researchers generated human iPSCs from peripheral blood mononuclear cells obtained from a patient carrying compound heterozygous variants of USH2A c.2299delG and c.1256G>T and the patient’s healthy sibling.

[Heliyon] Researchers ivestigated the immune response in acute or convalescent COVID19 patients. They characterized the peripheral blood mononuclear cells using flow cytometry and found that CD8+ T cells were significantly subsided in moderate COVID-19 and convalescent patients.

[Stem Cell Research] Researchers generated three human-iPSC lines from peripheral blood mononuclear cells of two long QT syndrome type 2 (LQT2) patients carrying pathogenic variants and one LQT2 patient carrying a variant of uncertain significance in KCNH2.

[Scientific Reports] Scientists investigated transcription profiles from peripheral blood mononuclear cells (PBMCs) of 8 patients with hepatocellular carcinoma and PBMCs from co-culture model with hepatocellular carcinoma using RNA-Sequencing.