Tag results:
PD-L1
Cell Therapy News
Sulforaphane Enhances the Antitumor Response of Chimeric Antigen Receptor T Cells by Regulating PD-1/PD-L1 Pathway
[BMC Medicine] The effect of combined SFN and CAR-T cells was determined in vitro using a co-culture system and in vivo using a xenograft mouse model. They furthered validated the effects of combination therapy in patients with cancer.
Mammary Cell News
Addition of Immunotherapy to Chemotherapy for Metastatic Triple-Negative Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
[Critical Reviews in Oncology Hematology] The authors conduct a meta-analysis, showing that the addition of programmed death-1/programmed death ligand-1 (PD-L1) blockade to chemotherapy improves progression-free survival in PD-L1 positive metastatic TNBC patients, also in the intention-to-treat population.
Human Immunology News
B7-H3 Suppresses Anti-Tumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression
[Cancer Immunology Research] Transcriptome analysis revealed that B7-H3 was highly expressed in PD-L1-low, non-immunoreactive high-grade serous ovarian cancer tumors, and its expression negatively correlated with an IFNγ signature, which reflected the tumor immune-reactivity.
Organoid News
Empirical Identification and Validation of Tumor-Targeting T Cell Receptors from Circulation Using Autologous Pancreatic Tumor Organoids
[Journal For Immunotherapy of Cancer] Autologous tumor organoids were stimulated with T cells from the patients’ peripheral blood for two weeks to generate the organoid-primed T cells.
Dermal Cell News
BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
[Cancer Research] Emerging evidence indicates B cell activating factor (BAFF) to be an important cytokine for anti-tumor immunity. The authors generated a BAFF-overexpressing B16.F10 melanoma cell model and found that BAFF-expressing tumors grew more slowly in vivo than control tumors.
Immune Regulation News
GOLM1 Exacerbates CD8+ T Cell Suppression in Hepatocellular Carcinoma by Promoting Exosomal PD-L1 Transport into Tumor-Associated Macrophages
[Signal Transduction and Targeted Therapy] Golgi membrane protein 1 (GOLM1) was positively correlated with infiltrating tumor-associated macrophages expressed high levels of programmed death-ligand 1 (PD-L1) and CD8+ T cell suppression in hepatocellular carcinoma tissues.