PI3K

[Nature Communications] Researchers investigated how an Alzheimer's disease-linked mutation deregulated expression of circadian genes and induced cognitive decline using the knock-in mice heterozygous for presenilin 2 N141I mutation.

[Bioengineered] The prostatic epithelial cell RWPE-1 and prostate cancer cell DU145 were exposed to Fraxetin to detect the changes in cell viability using cell counting kit-8 assay.

[Molecular Omics] Overexpression of miR-4732-5p significantly inhibited the migration, invasion, and metastasis of lung adenocarcinoma in vitro and in vivo, which could be reversed by overexpression of xenotropic and polytropic retrovirus receptor 1 (XPR1).

[Molecular Oncology] Targeting ubiquitin carboxyl-terminal hydrolase 28 (USP28) protein abundance at an early stage via inhibition of its activity is a feasible strategy for the treatment of early-stage lung tumors.

[Haematologica] Scientists investigated the oncogenic function of TAL1 and the possible cooperation with PI3K-AKT pathway activation using isogenic pro-T cell cultures ex vivo and in vivo leukemia models.

[Oxidative Medicine and Cellular Longevity] Scientists explored the effect of the plasma-activated medium on lung cancer cells in vitro and in vivo by using a 3D cell culture model.