PI3K

[Nature Communications] The authors demonstrated that lymphoid-restricted mutant IL7R, expressed at physiological levels in conditional knock-in mice, established a pre-leukemic stage in which B cell precursors displayed self-renewal ability, initiating leukemia resembling PAX5 P80R or Ph-like human B-acute lymphoblastic leukemia.

[British Journal of Nutrition] Researchers investigated the role and underlying molecular mechanism of Tau on protein synthesis and proliferation of C2C12 myoblast cells.

[Journal of Biomaterials Applications] Scientists aimed to improve the sensitivity and efficacy of chemotherapeutic drugs through the inhibition of autophagy. They suggested that the amphiphilic peptide micelle systems developed in this study had the potential to combine autophagy inhibition and chemotherapy in cancer treatment, especially for prostate cancer.

[Evidence-Based Complementary and Alternative Medicine] The expression level of relative proteins in mTOR pathway was detected by western blot assay to investigate the mechanism of Qingjie Fuzheng granule effect on colorectal cancer cells.

[PLoS One] Activated hepatic stellate cell cell lines were used to evaluate the effects of tenofovir disoproxil fumarate and entecavir. After treatment with each antiviral agent, cell viability, morphology, apoptotic features, autophagy and antifibrosis signaling pathways were examined.

[iScience] Researchers investigated Smurf1 expression in various glioblastoma (GB) cell lines and patient tissues and found Smurf1 loss elevated PTEN levels that interrupted the epidermal growth factor receptor pathway activity.