Smurf1 Silencing Restores PTEN Expression That Ameliorates Progression of Human Glioblastoma and Sensitizes Tumor Cells to mTORC1/C2 Inhibitor Torin1

Researchers investigated Smurf1 expression in various glioblastoma (GB) cell lines and patient tissues and found Smurf1 loss elevated PTEN levels that interrupted the epidermal growth factor receptor pathway activity.