PI3K

[Cellular Signalling] The authors explored the PDGF-PDGFR gene expression changes and their involvement in skeletal muscle myogenesis and myogenic fate.

[Oncogenesis] Scientists suggested that the dual inhibition of HDAC and HSP90 could suppress the expression of oncogenic pathways in acute leukemia, and MPT0G449 represented a novel therapeutic for anticancer treatment.

[Scientific Reports] The authors investigated the role of mechanical forces in altering the chemoresistance, proliferation and metastasis of breast cancer cells and used high throughput mechanobiological screens to identify pathways that could be targeted to reduce the effects of load.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists used the invadopodium model system of Src-transformed fibroblast and MDA-MB-231 cell lines to investigate the functional role of PI(3,4)P2 in adhesion signaling.

[Cell Death & Disease] Scientists reported that blocking PD-1/PD-L1 interaction between myeloid-derived suppressor cells and B cells could reverse the immunosuppressive functions of PD-1−PD-L1+ Bregs.

[Scientific Reports] identify regulators of intact amyloid-β40/42 (Aβ) levels in A549 (p53 wild-type) and H1299 (p53-null) lung cancer cell media.