PTEN

[Nature Communications] Researchers demonstrated that a large subset of TNBC expressed significant levels of MAPK4, and this expression was critical for driving AKT activation independent of PI3K and promoting TNBC cell and xenograft growth.

[Molecular Biology and Evolution] Scientists showed the molecular evolution of NCK-interacting kinase-related kinase, which confered its function for inhibiting placental cell proliferation.

[Cell Death Discovery] Scientists demonstrated the effects of amyloid precursor protein-derived C-terminal fragments (APP-CTFs)-related pathology using induced neural stem cells (iNSCs) from Alzheimer’s disease patient-derived fibroblasts.

[Bioengineered] Researchers clarified the role of hydroxysafflor yellow A in inhibiting colorectal cancer in vitro and the underlying mechanisms.

[iScience] Researchers investigated Smurf1 expression in various glioblastoma (GB) cell lines and patient tissues and found Smurf1 loss elevated PTEN levels that interrupted the epidermal growth factor receptor pathway activity.

[Molecular Therapy-Nucleic Acids] The effect of PTEN on prostate cancer (PCa) cell migration, apoptosis and the cell cycle was analyzed in vitro using a wound healing assay and flow cytometry. The authors assessed the ability of intraprostatic and intratumoral injection of recombinant adeno-associated virus (rAAV) 9 expressing Pten or Cdkn1b to inhibit PCa progression.