PTEN

[Immunopharmacology and Immunotoxicology] The authors revealed the function of bone marrow MSC-derived exosomes in sepsis-induced myocardial injury and the molecular mechanism.

[npj Precision Oncology] Researchers showed that PERK plays a critical role in BRAF inhibitor-acquired resistance in melanoma with impaired PTEN.

[Endocrinology] Estradiol (E2) and the clinically used selective estrogen receptor modulator toremifene increased miR-486 in undifferentiated and differentiated myoblast cell line C2C12 and E2-inducible expression correlated with direct binding of estrogen receptor alpha to the regulatory region of miR-486 gene.

[Advanced Science] A low-cost protocol for cardiomyocyte differentiation from mouse ESCs is presented and it is shown that Pten deletion potently suppressed cardiomyocyte differentiation.

[Scientific Reports] Researchers found that Stathmin (STMN1) was overexpressed in lung cancer tissues and associated with worse survival rates of lung cancer patients.

[Nature Communications] In both ERG positive VCaP cells and ERG/PTEN mice, PTEN loss results in AKT activation and EZH2 phosphorylation at serine 21 that favors ERG methylation.