Parkinson's disease

[Scientific Reports] Using an RNA-seq platform, scientists identified and validated the differential gene expression of five transcription factors that were associated with a remarkable increase in the number of iPSC colonies generated from a patient with Parkinson's disease.

[Stem Cell Reports] Investigators showed proof of concept of human glial progenitor cells (hGPCs) conversion using fetal cells and also established a renewable and reproducible stem cell-based hGPC system for direct neural conversion in vitro.

[Seelos Therapeutics, Inc.] Seelos Therapeutics, Inc. announced the signing of a Sponsored Research Agreement with Duke University to use the MPTP-induced Parkinson's Disease (PD) mouse model to establish in vivo proof-of-concept study to demonstrate that administration of LV-dCas9-DNMT3A virus can prevent and/or delay PD and test the efficacy and safety of SLS-004. Subsequently, other pre-clinical models would be utilized to further validate the investigational product.

[Scientific Reports] To elucidate the role of S-nitrosylated parkin and divalent metal transporter 1 in Parkinson's disease, SH-SY5Y cells were transfected with parkin, being treated with S-nitrosoglutathione and 1-methyl-4-phenylpyridinium (MPP+).

[Seelos Therapeutics Inc.] Seelos Therapeutics, Inc. announced the signing of a Sponsored Research Agreement with Duke University to use the MPTP-induced Parkinson's Disease (PD) mouse model to establish in vivo proof-of-concept study to demonstrate that administration of LV-dCas9-DNMT3A virus can prevent and/or delay PD and test the efficacy and safety of SLS-004.

[Journal of Neuroscience Research] Investigators examined the protective effect of noradrenaline against H2O2‐induced neurotoxicity using two different mixed cultures: the mixed culture of human astrocytoma U‐251 MG cells and human neuroblastoma SH‐SY5Y cells, and the mouse primary cerebrum mixed culture of neurons and astrocytes.