RAGE

[American Journal of Physiology-Lung Cellular and Molecular Physiology] The effects of the RAGE ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] The effects of the receptor for advanced glycation end-products (RAGE) ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.

[Cell Death & Disease] Scientists found a decrease in endothelial cells and an increase in cells co-expressing CD31 and α-smooth muscle actin at eight weeks in heart tissue of mice subjected to transverse aortic constriction, which implied EndMT.

[JCI Insight] Scientists carried out a nested cohort study within a Phase IIa safety trial of treatment with allogeneic MSCs for moderate to severe ARDS.

[Environmental Toxicology] Investigators evaluated the effects of purified verbascoside on human prostate cancer and the associated molecular mechanisms.

[Scientific Reports] To overcome the scarcity of primary human alveolar epithelial cells for lung research, and the limitations of current cell lines to recapitulate the phenotype, functional and molecular characteristics of the healthy human alveolar epithelium, the authors developed a new method to immortalise primary human alveolar epithelial lung cells using a non-viral vector to transfect the telomerase catalytic subunit and the simian virus 40 large-tumor antigen.