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Pulmonary Cell NewsThe effects of the receptor for advanced glycation end-products (RAGE) ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
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Pouwels, S. D., Hesse, L., Wu, X., Allam, V. S. R. R., van Oldeniel, D., Bhiekharie, L. J., Phipps, S., Oliver, B. G. G., Gosens, R., Sukkar, M., & Heijink, I. H. (2021). LL-37 and HMGB1 induce alveolar damage and reduce lung tissue regeneration via RAGE. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.00138.2021 Cite
