Hedgehog Interacting Protein (HHIP) Represses Airway Remodeling and Metabolic Reprogramming in COPD-Derived Airway Smooth Muscle Cells

Researchers suggest that HHIP repressed aerobic glycolysis and airway smooth muscle cells hyperplasia, which might contribute to the increased airway remodeling in Hhip+/- mice.
[Scientific Reports]
Li, Y., Zhang, L., Polverino, F., Guo, F., Hao, Y., Lao, T., Xu, S., Li, L., Pham, B., Owen, C. A., & Zhou, X. (2021). Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells. Scientific Reports, 11(1), 9074. https://doi.org/10.1038/s41598-021-88434-x Cite
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Small Airway Determinants of Airflow Limitation in Chronic Obstructive Pulmonary Disease

Small airways from patients with COPD showed thickening of epithelial and subepithelial tissue, mucus plugging and reduced collagen density in the airway wall in severe COPD.
[Thorax]
Polosukhin, V. V., Gutor, S. S., Du, R.-H., Richmond, B. W., Massion, P. P., Wu, P., Cates, J. M., Sandler, K. L., Rennard, S. I., & Blackwell, T. S. (2021). Small airway determinants of airflow limitation in chronic obstructive pulmonary disease. Thorax. https://doi.org/10.1136/thoraxjnl-2020-216037 Cite
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HIV Induces Airway Basal Progenitor Cells to Adopt an Inflammatory Phenotype

Researchers hypothesized that HIV induced the basal stem/progenitor cells to express inflammatory mediators that contributed to the pathogenesis of emphysema.
[Scientific Reports]
Chung, N. P. Y., Khan, K. M. F., Kaner, R. J., O’Beirne, S. L., & Crystal, R. G. (2021). HIV induces airway basal progenitor cells to adopt an inflammatory phenotype. Scientific Reports, 11(1), 3988. https://doi.org/10.1038/s41598-021-82143-1 Cite
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ADAM17 Deficiency Protects Against Pulmonary Emphysema

Histological, immunohistochemical, immunofluorescence and molecular analyses, as well as lung function tests, were performed to assess pulmonary emphysema, inflammation and alveolar cell apoptosis.
[American Journal of Respiratory Cell and Molecular Biology]
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Identification of AAV Serotypes for Lung Gene Therapy in Human Embryonic Stem Cell-Derived Lung Organoids

Scientists screened the ability of multiple adeno-associated virus serotypes to transduce lung bud organoids, a model of human lung parenchyma generated from human embryonic stem cells.
[Stem Cell Research & Therapy]
Meyer-Berg, H., Zhou Yang, L., Pilar de Lucas, M., Zambrano, A., Hyde, S. C., & Gill, D. R. (2020). Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids. Stem Cell Research & Therapy, 11(1), 448. https://doi.org/10.1186/s13287-020-01950-x Cite
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Gene Therapy for Alpha 1-Antitrypsin Deficiency with an Oxidant-Resistant Human Alpha 1-Antitrypsin

Scientists hypothesized that a onetime administration of a serotype 8 adeno-associated virus gene transfer vector coding for the oxidation-resistant variant alpha 1-antitrypsin (AAT) would maintain antiprotease activity under oxidant stress compared with normal AAT.
[JCI Insight]
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Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence

Researchers investigated whether the pharmacological sirtuin 1 activator SRT2104 protects against Type II alveolar epithelial cell senescence in rats with emphysema.
[COPD-Journal of Chronic Obstructive Pulmonary Disease]
Gu, C., Zhang, Q., Ni, D., Xiao, Q.-F., Cao, L.-F., Fei, C.-Y., Ying, Y., Li, N., & Tao, F. (2020). Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. COPD: Journal of Chronic Obstructive Pulmonary Disease, 0(0), 1–8. https://doi.org/10.1080/15412555.2020.1797657 Cite
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