ADAM17 Deficiency Protects Against Pulmonary Emphysema

Histological, immunohistochemical, immunofluorescence and molecular analyses, as well as lung function tests, were performed to assess pulmonary emphysema, inflammation and alveolar cell apoptosis.
[American Journal of Respiratory Cell and Molecular Biology]
ADAM17 Deficiency Protects Against Pulmonary Emphysema | American Journal of Respiratory Cell and Molecular Biology | Articles in Press. (n.d.). Retrieved November 19, 2020, from https://www.atsjournals.org/doi/pdf/10.1165/rcmb.2020-0214OC Cite
Abstract
Bookmark

No account yet? Register

0
Share

Identification of AAV Serotypes for Lung Gene Therapy in Human Embryonic Stem Cell-Derived Lung Organoids

Scientists screened the ability of multiple adeno-associated virus serotypes to transduce lung bud organoids, a model of human lung parenchyma generated from human embryonic stem cells.
[Stem Cell Research & Therapy]
Meyer-Berg, H., Zhou Yang, L., Pilar de Lucas, M., Zambrano, A., Hyde, S. C., & Gill, D. R. (2020). Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids. Stem Cell Research & Therapy, 11(1), 448. https://doi.org/10.1186/s13287-020-01950-x Cite
Full Article
Bookmark

No account yet? Register

0
Share

Gene Therapy for Alpha 1-Antitrypsin Deficiency with an Oxidant-Resistant Human Alpha 1-Antitrypsin

Scientists hypothesized that a onetime administration of a serotype 8 adeno-associated virus gene transfer vector coding for the oxidation-resistant variant alpha 1-antitrypsin (AAT) would maintain antiprotease activity under oxidant stress compared with normal AAT.
[JCI Insight]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence

Researchers investigated whether the pharmacological sirtuin 1 activator SRT2104 protects against Type II alveolar epithelial cell senescence in rats with emphysema.
[COPD-Journal of Chronic Obstructive Pulmonary Disease]
Abstract
Bookmark

No account yet? Register

0
Share
Share