Gene Therapy for Alpha 1-Antitrypsin Deficiency with an Oxidant-Resistant Human Alpha 1-Antitrypsin

Scientists hypothesized that a onetime administration of a serotype 8 adeno-associated virus gene transfer vector coding for the oxidation-resistant variant alpha 1-antitrypsin (AAT) would maintain antiprotease activity under oxidant stress compared with normal AAT.
[JCI Insight]
Sosulski, M. L., Stiles, K. M., Frenk, E. Z., Hart, F. M., Matsumura, Y., De, B. P., Kaminsky, S. M., & Crystal, R. G. (2020). Gene therapy for alpha 1-antitrypsin deficiency with an oxidant-resistant human alpha 1-antitrypsin. JCI Insight, 5(15). https://doi.org/10.1172/jci.insight.135951 Cite
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Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence

Researchers investigated whether the pharmacological sirtuin 1 activator SRT2104 protects against Type II alveolar epithelial cell senescence in rats with emphysema.
[COPD-Journal of Chronic Obstructive Pulmonary Disease]
Gu, C., Zhang, Q., Ni, D., Xiao, Q.-F., Cao, L.-F., Fei, C.-Y., Ying, Y., Li, N., & Tao, F. (2020). Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. COPD: Journal of Chronic Obstructive Pulmonary Disease, 0(0), 1–8. https://doi.org/10.1080/15412555.2020.1797657 Cite
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