Knockout RAGE Alleviates Cardiac Fibrosis through Repressing Endothelial-to-Mesenchymal Transition (EndMT) Mediated by Autophagy

By
Justin.choi
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Scientists found a decrease in endothelial cells and an increase in cells co-expressing CD31 and α-smooth muscle actin at eight weeks in heart tissue of mice subjected to transverse aortic constriction, which implied EndMT.
[Cell Death & Disease]
Zhang, L., He, J., Wang, J., Liu, J., Chen, Z., Deng, B., Wei, L., Wu, H., Liang, B., Li, H., Huang, Y., Lu, L., Yang, Z., Xian, S., & Wang, L. (2021). Knockout RAGE alleviates cardiac fibrosis through repressing endothelial-to-mesenchymal transition (EndMT) mediated by autophagy. Cell Death & Disease, 12(5), 1–13. https://doi.org/10.1038/s41419-021-03750-4 Cite
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