RAS

[Leukemia] The authors found that the RNA-binding protein IGF2BP3, which was overexpressed in mixed-lineage leukemia (MLL)-translocated leukemia, strongly amplified MLL-Af4-mediated leukemogenesis.

[Oncology Reports] Scientists determined the effects of miR‑7515 on pancreatic cancer cell proliferation, invasion and migration in vitro and in vivo, and investigated its underlying molecular mechanism using bioinformatics, double luciferase assay and western blotting.

[Clinical Cancer Research] Scientists performed transcriptional profiling of tumors from a Phase II clinical trial of platinum chemotherapy for advanced TNBC, revealing a gene expression signature that identified de novo chemorefractory tumors.

[NPJ Genomic Medicine] Researchers provided a catalog of driver genes in cutaneous squamous cell carcinoma, offering points of therapeutic intervention and insights into the biology of cutaneous squamous cell carcinoma.

[npj Precision Oncology] Researchers provided in-depth investigation of copy number alteration heterogeneity in phenotypically characterized circulating tumor cells at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors in ALK-positive non-small cell lung cancer.

[Cell Reports] Using patient-derived human induced pluripotent stem cell-forebrain cerebral organoids (hCOs), researchers identified both neural stem cell proliferation and neuronal maturation abnormalities in neurofibromatosis type 1-total gene deletion hCOs.