RAS

[Scientific Reports] Gastric cancer (GC) is one of the most lethal malignant tumors. Researchers identified novel driver genes and clarified their roles in GC.

[Aging-Us] The authors found that conditioned medium harvested from WI-38 lung fibroblasts and H1299 lung adenocarcinoma cells exposed to 0.1Gy to 1Gy could enhance the migration and invasion of unirradiated H1299 cells in both 2D and 3D culturing circumstances.

[Erasca, Inc.] Erasca, Inc. announced dosing of the first patient in HERKULES-3, a Phase Ib/II master protocol clinical trial evaluating ERAS-007 in combination with various agents in patients with gastrointestinal cancer, with initial focus on patients with advanced colorectal cancer.

[Molecular Carcinogenesis] Researchers reported that the Rho-associated protein kinase (ROCK) signaling pathway was a critical regulator of oncogene-induced senescence in skin carcinogenesis.

[Proceedings of the National Academy of Sciences of the United States of America] Using a combination of in vitro and in vivo assays, scientists demonstrate that Tspan6 functioned as a tumor suppressor in colorectal cancer by attenuating the epidermal growth factor receptor–based signaling axis.

[Cell Death Discovery] TNBC cells treated with doxorubicin exhibited reduced branched-chain ketoacid dehydrogenase kinase (BCKDK) expression and intracellular branched-chain ketoacids (BCKAs). Genetic and pharmacological inhibition of BCKDK in TNBC cell lines also showed a similar reduction in intracellular and secreted BCKAs.