ROS production

[Frontiers in Imm] The authors demonstrated that Mycobacterium tuberculosis infection triggered a time-dependent reduction in the expression of focal adhesion kinase in human macrophages.

[Cell Death & Disease] Investigators presented the role of the actin-regulating protein cofilin1 in regulating mitochondrial pathways in oxidative neuronal death.

[Acta Pharmacologica Sinica] The authors showed that interrupting TRPV4–Nox2 coupling by TRPV4 knockout, or by treatment with a specific Nox2 inhibitor Nox2 dstat or a specific TRPV4 inhibitor HC067046 significantly attenuated obesity-induced ROS overproduction in aortic endothelial cells, and reversed the abnormal endothelial cytoskeletal structure.

[Cellular Signalling] The authors revealed the mechanism of neutrophil extracellular traps generation and their role in trophoblast apoptosis in gestational diabetes mellitus.

[Evidence-Based Complementary and Alternative Medicine] As a traditional Chinese medicine prescription, Xiao-Xu-Ming decoction (XXMD) could reduce the incidence of lung infection of patients with cerebral infarction. In vitro, human pulmonary alveolar epithelial cells were treated with XXMD and were followed by lipopolysaccharide treatment.

[European Journal of Pharmaceutical Sciences] Scientists explored the specific mechanism of doxorubicin in osteoarthritis (OA). A mouse OA model was established by destabilizing the medial meniscus, and the role of DOX was determined by intraperitoneally injecting five or ten mg/kg DOX.