SCLC

[Oncogene] Researchers investigated the function of the oncogenic BAP1/ASXL3/BRD4 epigenetic axis in small cell lung cancer by developing a next-generation BAP1 inhibitor.

[Science Advances] Scientists demonstrated that EP300 mutants lacking acetyltransferase domain accelerated tumor development in mouse models of SCLC.

[Molecular Biology Reports] Researchers demonstrated that As2O3 had a remarkable inhibitory effect on tumor initiating cells of small cell lung cancer both in vitro and in vivo, and the mechanism might have involved the down-regulation of Notch pathway

[Molecular Biology Reports] The effects of ErPC3 in NSCLC cell line A549 and SCLC cell line DMS 114 in terms of cell viability, induction of apoptosis, cell cycle phase distribution, gene and protein expression levels, and migration capacity were investigated. 25 µM ErPC3 exhibited dose-dependent cytotoxicity against in both cancer cells.

[Acta Pharmacologica Sinica] Researchers investigated how schlafen family member 11 (SLFN11) expression regulated the sensitivity of small cell lung cancer to topotecan.

[Nature Communications] Scientists exploited six paired pre-treatment and post-chemotherapy circulating tumor cell patient-derived explant models from donors with extensive stage small cell lung cancer to investigate changes at disease progression after chemotherapy.