SCLC

[Biomedicine & Pharmacotherapy] The authors discuss the experimental models of lung cancer and metastasis, mechanisms in SCLC transfer and the challenges about clinical management of lung cancer.

[Clinical Epigenetics] Researchers uncovered that FK228 sensitized human radioresistant SCLC cells to radiation mainly through induction of chromatin decondensation and suppression of DNA damage signaling and repair.

[Translational Oncology] Investigators clarified the role of neuron-specific enolase (NSE) in the progression of SCLC and found that NSE expression was positively correlated with distant metastasis.

[Cancer Cell] Using tumor expression data and non-negative matrix factorization, scientists identified four small cell lung cancer (SCLC) subtypes defined largely by differential expression of transcription factors ASCL1, NEUROD1, and POU2F3 or low expression of all three transcription factor signatures accompanied by an Inflamed gene signature.

[Ipsen] Ipsen announced the FDA has granted the company Fast Track designation for irinotecan liposome injection in study patients with SCLC who progressed following a first-line platinum-based regimen, reflecting the unmet medical need.

[British Journal of Cancer] Researchers investigated the potential effect of combining Rovalpituzumab tesirine and CBL0137 in small cell lung cancer to eradicate tumor-initiating cells more effectively.