STAT3

[Cancer Gene Therapy] The expression of miR-548ac and TRIM28 and the targeting relationship were identified, and the results demonstrated that the expression of miR-548ac was upregulated in acute myeloid leukemia (AML) cell lines and AML cell-secreted extracellular vesicles compared with CD34+ HSCs.

[Blood] Scientists analyzed the effect of decitabine on T-cell subpopulations in immune thrombocytopenia in vitro and in vivo. They found that low-dose decitabine promoted the generation and differentiation of regulatory T cells and augmented their immunosuppressive function.

[International Journal of Molecular Medicine] The hepatocytes of acetaminophen (APAP)‑injected mice were isolated for reverse transcription‑quantitative PCR and western blot analyses. For the in vitro study, primary hepatocytes isolated from WT or fat‑1 mice were stimulated with APAP.

[Cancer Research] Researchers identified decaprenyl diphosphate synthase subunit 1 (PDSS1) as an essential gene for TNBC metastasis. PDSS1 expression was significantly upregulated in TNBC tissues compared to adjacent normal tissues and was positively associated with poor survival among TNBC patients.

[Molecular Carcinogenesis] Scientists showed that methylseleninic acid substantially attenuated cisplatin-induced PD-L1 expression via inhibiting protein kinase B phosphorylation, thereby potentiated cisplatin cytotoxicity in prostate and lung cancer cell models.

[Nature Communications] Visceral adipose-derived factors promoted vasculogenesis and the onset of metastatic dissemination by activation of STAT3, which inhibited miR-200a and enhanced ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.