Scientists showed that methylseleninic acid substantially attenuated cisplatin-induced PD-L1 expression via inhibiting protein kinase B phosphorylation, thereby potentiated cisplatin cytotoxicity in prostate and lung cancer cell models.
[Molecular Carcinogenesis]
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Hu, W., Ma, Y., Zhao, C., Yin, S., & Hu, H. (n.d.). Methylseleninic acid overcomes programmed death-ligand 1-mediated resistance of prostate cancer and lung cancer. Molecular Carcinogenesis, n/a(n/a). https://doi.org/10.1002/mc.23340 Cite