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Pulmonary Cell NewsVisceral adipose-derived factors promoted vasculogenesis and the onset of metastatic dissemination by activation of STAT3, which inhibited miR-200a and enhanced ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.
[Nature Communications]
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Di Franco, S., Bianca, P., Sardina, D. S., Turdo, A., Gaggianesi, M., Veschi, V., Nicotra, A., Mangiapane, L. R., Lo Iacono, M., Pillitteri, I., van Hooff, S., Martorana, F., Motta, G., Gulotta, E., Lentini, V. L., Martorana, E., Fiori, M. E., Vieni, S., Bongiorno, M. R., … Stassi, G. (2021). Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery. Nature Communications, 12(1), 5006. https://doi.org/10.1038/s41467-021-25333-9 Cite
