STAT3

[Signal Transduction and Targeted Therapy] Via binding to CD147, TFF3 enhanced CD147-CD44s interaction, resulting in signal transducer and activator of transcription 3 activation and prostaglandin G/H synthase 2 expression, which were indispensable for TFF3-induced colorectal cancer migration, proliferation, and invasion.

[Phytotherapy Research] Scientists focused on the regulatory effects of parthenolide, a bioactive component derived from Chrysanthemum parthenium L., against hepatic fibrosis via regulating the crosstalk of toll-like receptor 4 and signal transducer and activator of transcription 3 in activated hepatic stellate cells.

[RNA Biology] Researchers discovered that ZBED3 antisense RNA 1 (ZBED3-AS1) was overexpressed in melanoma cells compared with human epidermal melanocytes.

[Journal of Cellular and Molecular Medicine] Researchers integrated text mining data, protein-protein interaction networks and multi-experiment microarray data to specify candidate genes that were involved in VEGFA/VEGFR2 signalling pathways.

[Journal of Pathology] Scientists demonstrated that periostin was markedly upregulated in diethylnitrosamine (DEN)-induced mouse hepatocellular carcinoma tissues (HCC) and periostin knockout impaired DEN-induced HCC development.

[Scientific Reports] Scientists generated IL11 knockout (Il11−/−) mice that were born in expected ratios and have normal hematological profiles. Lung fibroblasts from Il11−/− mice were resistant to pro-fibrotic stimulation with TGFβ1.